Nakao S, Tanaka H, Tahara M, Yoshimura H, Sakurai S, Tei C, Kashima T
Circulation. 1983 Apr;67(4):860-5. doi: 10.1161/01.cir.67.4.860.
Acute aortic regurgitation was created experimentally in 21 mongrel dogs to examine the relationship of the regurgitant jet to observed echocardiographic findings. The direction of the regurgitant jet was studied by echo contrast injections in the aortic root. Diastolic fluttering of the anterior mitral leaflet (AML) was noted in all 21 dogs irrespective of direction of the jet. Diastolic fluttering of the interventricular septum (IVS) was noted in six of the seven dogs with a tear of the noncoronary cusp and in one of seven dogs with lesions in the left coronary cusp. In all seven dogs with echocardiographically demonstrated IVS fluttering, a regurgitant jet impinged on the anterior part of the IVS. Amplitude of the AML excursion was not significantly different from control when the lesions involved the noncoronary or the left coronary cusps. However, all seven dogs that had a lesion in the right coronary cusp demonstrated a significant reduction in the amplitude of the AML excursion. The regurgitant jet in these dogs impinged uniformly on the AML. We conclude that diastolic fluttering of the AML is uniformly observed and unrelated to the direction of the regurgitant jet, diastolic fluttering of the IVS is caused by the regurgitant jet impinging upon the IVS, and amplitude of the AML may be reduced as a result of a jet impingement of the AML.
通过实验在21只杂种犬身上制造急性主动脉瓣反流，以研究反流束与观察到的超声心动图结果之间的关系。通过向主动脉根部注射超声造影剂来研究反流束的方向。在所有21只犬中均观察到二尖瓣前叶（AML）的舒张期扑动，与反流束的方向无关。在7只非冠状动脉瓣叶撕裂的犬中有6只以及7只左冠状动脉瓣叶有病变的犬中有1只观察到室间隔（IVS）的舒张期扑动。在所有7只经超声心动图证实有IVS扑动的犬中，反流束撞击在IVS的前部。当病变累及非冠状动脉瓣叶或左冠状动脉瓣叶时，AML的摆动幅度与对照组相比无显著差异。然而，所有7只右冠状动脉瓣叶有病变的犬均显示AML摆动幅度显著降低。这些犬中的反流束均匀地撞击在AML上。我们得出结论，AML的舒张期扑动普遍可见且与反流束的方向无关，IVS的舒张期扑动是由反流束撞击IVS引起的，AML的幅度可能因反流束撞击AML而降低。
