Bobba V V, Krishnamurthy G T, Kingston E, Brown P H, Eklem M, Turner F E
Clin Nucl Med. 1983 Feb;8(2):70-5. doi: 10.1097/00003072-198302000-00008.
The biokinetics (blood clearance, urinary excretion, hepatic peak time, uptake, and excretion t-1/2) and the imaging parameters (the time of appearance of the common bile duct, gallbladder, and duodenum) were determined in 34 normal subjects using Tc-99m diethyl (EIDA), Tc-99m dimethyl (HIDA), Tc-99m paraisopropyl (PIPIDA), and Tc-99m parabutyl (PBIDA) iminodiacetic acid derivatives. The blood and hepatic clearance of the four agents were significantly different (P less than 0.05) from each other. The 24-hour urinary excretion of PBIDA was significantly lower (P less than 0.05) than the urinary excretion of the other three agents. There was no difference among the four agents in the time of appearance of the gallbladder and duodenum. The time of appearance of the common bile duct was significantly delayed with PBIDA. The maximum intensity of the common bile duct usually occurred between 20 to 40 minutes with all four agents. However, gallbladder intensity continued to increase up to 3 hours. It is concluded that in the presence of normal liver function, all four Tc-99m IDA agents show definite differences in biokinetics but these differences do not have a major effect on biliary imaging parameters. If imaging alone is the primary goal, the selection of any one of the four agents will meet the clinican's need satisfactorily.
采用锝-99m二乙基亚氨基二乙酸（EIDA）、锝-99m二甲基亚氨基二乙酸（HIDA）、锝-99m对异丙基亚氨基二乙酸（PIPIDA）和锝-99m对丁基亚氨基二乙酸（PBIDA），对34名正常受试者的生物动力学（血液清除率、尿排泄率、肝脏达峰时间、摄取率和排泄半衰期）及成像参数（胆总管、胆囊和十二指肠的显影时间）进行了测定。这四种药物的血液清除率和肝脏清除率彼此间有显著差异（P<0.05）。PBIDA的24小时尿排泄率显著低于其他三种药物（P<0.05）。四种药物在胆囊和十二指肠的显影时间上无差异。PBIDA使胆总管的显影时间显著延迟。使用所有四种药物时，胆总管的最大强度通常出现在20至40分钟之间。然而，胆囊的强度在3小时内持续增加。结论是，在肝功能正常的情况下，所有四种锝-99m亚氨基二乙酸类药物在生物动力学上均显示出明显差异，但这些差异对胆道成像参数没有重大影响。如果仅以成像为主要目标，选择这四种药物中的任何一种都能令人满意地满足临床医生的需求。
