Alloza J L, Lasagna L
Clin Pharmacol Ther. 1983 Mar;33(3):269-77. doi: 10.1038/clpt.1983.32.
Four widely used compendia of prescribing information have been received to examine the way in which some drug companies recommend uses for several anti-inflammatory products and describe the major dangers in their use. The Physician's Desk Reference (PDR) cites the greatest absolute number of indications for steroids with systemic action, as well as the greatest number of contraindications, warnings and precautions, and adverse effects. The total number of precautions appearing in the PDR is three times the mean for the other compendia, and the number of adverse effects is four times the mean of the others. Together, these other compendia contain 70.5% of the number of words in the PDR. The PDR contains statements that are strongly directive for the physician and that do not appear in the other compendia. Regulatory and social differences may at least partially explain these discrepancies.
已收到四份广泛使用的处方信息汇编，以研究一些制药公司推荐几种抗炎产品用途的方式，并描述其使用中的主要风险。《医师案头参考》（PDR）列出了具有全身作用的类固醇的绝对适应症数量最多，以及禁忌症、警告和注意事项以及不良反应的数量最多。PDR中出现的注意事项总数是其他汇编平均值的三倍，不良反应数量是其他汇编平均值的四倍。这些其他汇编总共包含PDR字数的70.5%。PDR包含对医生有强烈指导作用且未出现在其他汇编中的陈述。监管和社会差异可能至少部分解释了这些差异。
