Mattison D R, Nightingale M S, Shiromizu K
Environ Health Perspect. 1983 Feb;48:43-52. doi: 10.1289/ehp.834843.
Successful reproduction requires a complex series of interdependent physiological, cellular and molecular events. In the female many of these interdependent events are vulnerable to interruption by xenobiotic compounds. The physiological steps in the female reproductive cycle are reviewed. Selected xenobiotics which interrupt this cycle are presented and their mechanisms and site of adverse effects are discussed. Finally, a more detailed discussion of chemically induced ovarian failure in the human and an experimental animal model system is presented.
成功繁殖需要一系列复杂的相互依存的生理、细胞和分子事件。在雌性动物中，许多这些相互依存的事件容易受到外源性化合物的干扰。本文回顾了雌性生殖周期中的生理步骤。介绍了一些干扰该周期的特定外源性物质，并讨论了它们的作用机制和不良影响部位。最后，本文对人类和实验动物模型系统中化学诱导的卵巢功能衰竭进行了更详细的讨论。
