Chen Y T, Mattison D R, Feigenbaum L, Fukui H, Schulman J D
Science. 1981 Dec 4;214(4525):1145-7. doi: 10.1126/science.7302587.
When pregnant rats were fed a 50 percent galactose diet there was a striking reduction in oocyte number in the offspring. The most prominent effects were noted after exposure to galactose during the premeiotic stages of oogenesis. Prenatal exposure to galactose or its metabolites may contribute to the premature ovarian failure characteristic of human galactosemia.
当给怀孕的大鼠喂食含50%半乳糖的饮食时，其后代的卵母细胞数量显著减少。在卵子发生的减数分裂前期阶段接触半乳糖后，观察到了最显著的影响。产前接触半乳糖或其代谢产物可能导致人类半乳糖血症特有的卵巢早衰。
