铜蓝蛋白对微粒体脂质过氧化的抗氧化作用。
Antioxidant effect of caeruloplasmin on microsomal lipid peroxidation.
作者信息
Yamashoji S, Kajimoto G
出版信息
FEBS Lett. 1983 Feb 21;152(2):168-70. doi: 10.1016/0014-5793(83)80371-8.
PMID:6825843
Abstract
Microsomal NADPH-dependent lipid peroxidation catalyzed by ADP-Fe3+ was inhibited by the addition of caeruloplasmin. The antioxidant effect of caeruloplasmin was independent of the superoxide anion (O-2) scavenging activity. Since caeruloplasmin enhanced the function of ADP-Fe3+ acting as electron acceptor for microsomal electron transport system, the antioxidant effect of caeruloplasmin is considered to depend on the ferroxidase activity.
摘要
由ADP - Fe3+催化的微粒体NADPH依赖性脂质过氧化反应，通过添加铜蓝蛋白而受到抑制。铜蓝蛋白的抗氧化作用与超氧阴离子（O-2）清除活性无关。由于铜蓝蛋白增强了ADP - Fe3+作为微粒体电子传递系统电子受体的功能，因此认为铜蓝蛋白的抗氧化作用取决于其铁氧化酶活性。
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