克罗恩病患者与健康受试者唇部活检标本的免疫组织学 findings。（这里“findings”直接保留英文，因为没有更准确对应的中文词汇，结合语境理解为“结果”等意思较为合适）
Immunohistological findings in lip biopsy specimens from patients with Crohn's disease and healthy subjects.
作者信息
Crama-Bohbouth G, Bosman F T, Vermeer B J, van der Wal A M, Biemond I, Weterman I T, Peńa A S
出版信息
Gut. 1983 Mar;24(3):202-5. doi: 10.1136/gut.24.3.202.
Biopsies of apparently normal buccal mucosa were taken from 14 patients with Crohn's disease and 13 healthy controls who were matched for dental status. Most patients had an increased number of lymphocytes around vessels in the subepithelial tissue and two showed fibrosis with moderate atrophy of minor glands. Plasma cells which contained immunoglobulin, predominantly IgA, were only found around minor salivary glands in both patients and controls. Quantitative studies showed a significant increase in the number of cells containing IgA in patients compared with controls. No correlation was found between immunoglobulin pattern and disease activity, age, sex, or duration of Crohn's disease. A significant correlation was found between the activity of the disease, as defined by the Crohn's Disease Activity Index, and the number of plasma cells containing IgM.
从14例克罗恩病患者和13名牙齿状况匹配的健康对照者身上获取外观正常的颊黏膜活检样本。大多数患者上皮下组织血管周围淋巴细胞数量增加，两名患者出现纤维化伴小涎腺中度萎缩。含有免疫球蛋白（主要是IgA）的浆细胞仅在患者和对照者的小涎腺周围发现。定量研究表明，与对照者相比，患者中含IgA细胞的数量显著增加。未发现免疫球蛋白模式与疾病活动度、年龄、性别或克罗恩病病程之间存在相关性。根据克罗恩病活动指数定义的疾病活动度与含IgM浆细胞的数量之间存在显著相关性。
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