Kraemer R, Meister B, Schaad U B, Rossi E
J Pediatr. 1983 Mar;102(3):347-50. doi: 10.1016/s0022-3476(83)80646-5.
Extrinsic perennial bronchial asthma was studied by whole-body plethysmography in 118 patients to evaluate the degree and character of functional abnormalities during the asymptomatic "interval phase" of the disease. Study patients were divided into three functional subgroups, and the efficacy of albuterol (salbutamol), a beta-2-sympathomimetic drug, on bronchial obstruction of hyperinflation was analyzed. Response to medication was best in the group with predominant bronchial obstruction without hyperinflation. In contrast, patients with hyperinflation in the presence or absence of bronchial obstruction had only partial reversibility of their pathophysiologic alterations. Hyperinflation usually causes only minor clinical symptoms but tends to develop into irreversible lung damage in the form of "loss of elastic recoil." We suggest that early diagnosis and strict medical management in patients with hyperinflation are mandatory.
采用全身体积描记法对118例外因性常年性支气管哮喘患者进行研究，以评估疾病无症状“间歇期”功能异常的程度和特征。研究对象被分为三个功能亚组，并分析了β2-拟交感神经药物沙丁胺醇对过度充气性支气管阻塞的疗效。在以单纯支气管阻塞为主而无过度充气的组中，药物反应最佳。相比之下，无论有无支气管阻塞，存在过度充气的患者其病理生理改变仅有部分可逆性。过度充气通常仅引起轻微临床症状，但往往会发展为以“弹性回缩丧失”形式出现的不可逆肺损伤。我们建议，对存在过度充气的患者进行早期诊断和严格的药物治疗是必不可少的。
