Degraeve N, Moutschen J
Mutat Res. 1983 Mar;119(3):331-7. doi: 10.1016/0165-7992(83)90181-1.
The effects of dimethoate were investigated in the mouse after acute (10 mg/kg i.p.) or chronic treatment (0.6 ppm, 5 days a week for 7 weeks). Dominant lethal mutations were scored for a 7-week period after the acute dose, and immediately after exposure for the chronic dose. Chromosome damage was also analysed in bone marrow and spermatogonial cells at the same dose levels (from 12 to 48 h after treatment). MMS (60 mg/kg i.p.) was chosen as the positive control. In no experiment did dimethoate show any genotoxicity.
研究了乐果对小鼠急性（腹腔注射10毫克/千克）或慢性处理（0.6 ppm，每周5天，共7周）后的影响。急性剂量给药后7周以及慢性剂量暴露后立即对显性致死突变进行评分。在相同剂量水平（处理后12至48小时）对骨髓和精原细胞中的染色体损伤也进行了分析。选择甲基磺酸甲酯（腹腔注射60毫克/千克）作为阳性对照。在任何实验中乐果均未表现出任何遗传毒性。
