Shepard T H, Shiota K
Prog Clin Biol Res. 1983;110 Pt A:377-85.
The effect of thalidomide on a rat limb bud system has been studied in vitro. Thalidomide and adult monkey liver supernatants activated with cofactors for the mixed function monooxygenase system inhibited growth. Similar preparations from the rat did not inhibit growth. Planimetric measures of the surface area of limb buds were found to correlate closely with their protein contents. The ability to compare metabolizing systems from different mammals may be useful in extrapolating teratologic data between different species.
已在体外研究了沙利度胺对大鼠肢芽系统的作用。沙利度胺以及用混合功能单加氧酶系统的辅因子激活的成年猴肝脏上清液可抑制生长。来自大鼠的类似制剂则不抑制生长。发现肢芽表面积的平面测量值与其蛋白质含量密切相关。比较不同哺乳动物代谢系统的能力可能有助于推断不同物种间的致畸数据。
