Kurzynski T A, Cembrowski G S, Kimball J L
Am J Clin Pathol. 1983 Mar;79(3):370-4. doi: 10.1093/ajcp/79.3.370.
Two CIE procedures (CIE-1, CIE-2) for the detection of Clostridium difficile in diarrheal stools were evaluated by comparison to cytotoxin assay and culture results and by comparison to a clinical likelihood of C. difficile-induced diarrhea. Using a combination of toxin assay and culture results for reference, the CIE-1 and CIE-2 procedures had sensitivities of 33% and 47%, specificities of 89% and 91%, and positive predictive values of 42% and 54%, respectively. Using clinical likelihood for reference, the best results were obtained by the CIE-2 method, which yielded a positive predictive value of 77%. Neither CIE procedure provided an acceptable sensitivity for the detection of C. difficile in stools.
通过与细胞毒素检测和培养结果进行比较，并与艰难梭菌引起腹泻的临床可能性进行比较，对两种用于检测腹泻粪便中艰难梭菌的免疫酶标程序（CIE-1、CIE-2）进行了评估。以毒素检测和培养结果相结合作为参考标准，CIE-1和CIE-2程序的灵敏度分别为33%和47%，特异性分别为89%和91%，阳性预测值分别为42%和54%。以临床可能性作为参考标准，CIE-2方法取得了最佳结果，其阳性预测值为77%。两种CIE程序对于粪便中艰难梭菌的检测均未提供可接受的灵敏度。
