Behbehani M J, Heeley J D, Jordan H V
Am J Pathol. 1983 Mar;110(3):267-74.
The histopathologic features of experimental actinomycotic lesions produced in mice by Actinomyces israelii, Actinomyces naeslundii, and Actinomyces viscosus were examined. In lesions caused by A israelii the outer edge of the bacterial granule exhibited an eosinophilic fringe with no evidence of penetration of polymorphonuclear leukocytes (PMNs) into the bacterial granule. Chronic lesions after 6 weeks contained lobulated advancing fronts as well as areas of resolution showing heavy penetration by phagocytic cells. The number of macrophages and plasma cells in these lesions increased with time. In contrast, lesions caused by A viscosus and A naeslundii showed cellular evidence of resolution during the early stages of the infection (3-6 weeks). The bacterial core was readily penetrated and fragmented by PMNs in early A viscosus lesions. In lesions caused by A naeslundii there was less penetration of the central core by PMNs, and the bacterial granule tended to retain its structural integrity. Elongated crystals of hyaloid material appeared in lesions caused by all species. These protein-rich bodies appeared to be associated with resolving areas of the lesions. The observed contrast in the histopathologic appearance of actinomycotic lesions caused by A israelii, A naeslundii, and A viscosus is suggestive of important differences in the immune response of the host to infections caused by these three species.
对以色列放线菌、内氏放线菌和黏性放线菌在小鼠体内产生的实验性放线菌病变的组织病理学特征进行了检查。在由以色列放线菌引起的病变中，细菌颗粒的外缘呈现嗜酸性边缘，未见多形核白细胞（PMN）侵入细菌颗粒。6周后的慢性病变包含分叶状的进展前沿以及显示吞噬细胞大量浸润的消退区域。这些病变中巨噬细胞和浆细胞的数量随时间增加。相比之下，由黏性放线菌和内氏放线菌引起的病变在感染早期（3 - 6周）就显示出细胞消退的迹象。在早期黏性放线菌病变中，细菌核心容易被PMN穿透并破碎。在内氏放线菌引起的病变中，PMN对中央核心的浸润较少，细菌颗粒倾向于保持其结构完整性。在所有菌种引起的病变中均出现了透明样物质的细长晶体。这些富含蛋白质的物体似乎与病变的消退区域有关。观察到的由以色列放线菌、内氏放线菌和黏性放线菌引起的放线菌病变组织病理学外观的差异表明宿主对这三种菌种感染的免疫反应存在重要差异。
