Niewoehner D E, Peterson F J, Hoidal J R
Am Rev Respir Dis. 1983 Feb;127(2):227-30. doi: 10.1164/arrd.1983.127.2.227.
The early lung inflammatory response to cigarette smoke may be oxidant-mediated. We fed Syrian hamsters a diet deficient in selenium and vitamin E to determine whether impairment of the lung's antioxidant defenses might worsen inflammation induced by cigarette smoke. After 8 wk, cigarette-smoke-exposed animals had characteristic inflammatory lesions in the distal airways. Increased numbers of phagocytes, predominantly macrophages, were recovered by lavage and these cells exhibited enhanced oxidative metabolism. Animals fed the deficient diet had profound depletions of selenium and vitamin E, but no alterations in the histologic appearance of smoke-induced inflammatory lesions, in the numbers of phagocytes recruited, or in the oxidative metabolism of these phagocytes. These results suggest that selenium and vitamin E are unimportant in protecting against cigarette-smoke-induced lung injury.
早期肺部对香烟烟雾的炎症反应可能是由氧化剂介导的。我们给叙利亚仓鼠喂食缺乏硒和维生素E的饮食，以确定肺部抗氧化防御功能的损害是否会加重香烟烟雾引起的炎症。8周后，暴露于香烟烟雾的动物在远端气道出现典型的炎症病变。通过灌洗回收的吞噬细胞数量增加，主要是巨噬细胞，并且这些细胞表现出增强的氧化代谢。喂食缺乏饮食的动物体内硒和维生素E严重缺乏，但在烟雾诱导的炎症病变的组织学外观、募集的吞噬细胞数量或这些吞噬细胞的氧化代谢方面没有改变。这些结果表明，硒和维生素E在预防香烟烟雾引起的肺损伤方面并不重要。
