Reimann I W, Diener U, Frölich J C
Arch Gen Psychiatry. 1983 Mar;40(3):283-6. doi: 10.1001/archpsyc.1983.01790030053006.
The pharmacokinetic drug interactions between lithium sulfate and the nonsteroidal anti-inflammatory drugs (NSAIDs) indomethacin and aspirin were studied in ten normal female volunteers restricted to 150-mEq/day of sodium. Indomethacin decreased renal lithium ion elimination by 23% and caused a 40% increase in steady state plasma lithium ion levels. In contrast, aspirin had no effect on plasma lithium ion levels and increased renal lithium ion elimination by only 6%. Renal prostaglandin E2 excretion was suppressed by 50% to 60% of control levels by indomethacin and by 65% to 70% by aspirin. A clinically important drug interaction with the risk of lithium intoxication can occur between lithium salts and indomethacin. However, aspirin did not affect steady state plasma levels of lithium ion and thus may be preferable for antirheumatic treatment of patients undergoing long-term therapy with lithium salts. Frequent monitoring of plasma lithium ion levels is absolutely necessary in patients receiving both lithium salts and NSAIDs.
在10名每日钠摄入量限制为150毫当量的正常女性志愿者中，研究了硫酸锂与非甾体抗炎药（NSAIDs）吲哚美辛和阿司匹林之间的药代动力学药物相互作用。吲哚美辛使肾锂离子清除率降低23%，并使稳态血浆锂离子水平升高40%。相比之下，阿司匹林对血浆锂离子水平无影响，仅使肾锂离子清除率增加6%。吲哚美辛使肾前列腺素E2排泄量抑制至对照水平的50%至60%，阿司匹林使其抑制至65%至70%。锂盐与吲哚美辛之间可能发生具有锂中毒风险的临床重要药物相互作用。然而，阿司匹林不影响锂离子的稳态血浆水平，因此对于接受锂盐长期治疗的患者的抗风湿治疗可能更可取。接受锂盐和NSAIDs的患者绝对有必要频繁监测血浆锂离子水平。
