双氯芬酸对锂动力学的影响。
Effects of diclofenac on lithium kinetics.
作者信息
Reimann I W, Frölich J C
出版信息
Clin Pharmacol Ther. 1981 Sep;30(3):348-52. doi: 10.1038/clpt.1981.171.
The influence of the prostaglandin (PG) synthesis-inhibiting, nonsteroidal anti-inflammatory drug (NSAID) diclofenac on lithium kinetics was studied in five normal women on a 150-mEq sodium diet. Diclofenac decreased lithium renal clearance by 23% (P - 0.002) and increased lithium plasma levels by 26% (P - 0.001). Renal PG synthesis was suppressed by 53% of control values. These data show a clinically important drug interaction, possibly on the basis of a PG-dependent mechanism, with the risk of lithium intoxication for patients treated with lithium salts and NSAIDs.
在5名接受150毫当量钠饮食的正常女性中，研究了前列腺素（PG）合成抑制性非甾体抗炎药（NSAID）双氯芬酸对锂动力学的影响。双氯芬酸使锂的肾脏清除率降低了23%（P = 0.002），并使锂的血浆水平升高了26%（P = 0.001）。肾脏PG合成被抑制至对照值的53%。这些数据显示了一种具有临床重要性的药物相互作用，可能基于PG依赖性机制，对于接受锂盐和NSAIDs治疗的患者存在锂中毒风险。
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