Hull D S, Farkas S, Green K, Laughter L, Elijah R D, Bowman K
Arch Ophthalmol. 1983 Mar;101(3):479-81. doi: 10.1001/archopht.1983.01040010479032.
Radial keratotomy may cause anatomical damage to the rabbit corneal endothelium. To determine if physiological and functional alterations occur, radial keratotomy was performed on rabbit corneas using eight incisions with sparing of a 3.5-mm central pupillary area. Cornea endothelial membrane permeabilities were determined at various times up to ten weeks following the procedure using simultaneous flux determinations of tritiated inulin and dextran labeled with radioactive carbon on isolated corneas. At all times after radial keratotomy, there was no probable physiologically important change in corneal endothelial permeability to either of the labeled compounds. Fluorophotometry performed in a second group of animals at varying intervals following radial keratotomy showed no probable physiologically important change in endothelial fluorescein permeability. Aqueous humor turnover rate was reduced 16% and 29% at one week and nine to ten weeks, respectively, following radial keratotomy.
放射状角膜切开术可能会对兔角膜内皮造成解剖学损伤。为了确定是否会发生生理和功能改变，在兔角膜上进行放射状角膜切开术，做八个切口，保留3.5毫米的中央瞳孔区。在手术后长达十周的不同时间，使用氚标记的菊粉和放射性碳标记的右旋糖酐在离体角膜上同时进行通量测定，来确定角膜内皮膜的通透性。在放射状角膜切开术后的所有时间里，角膜内皮对任何一种标记化合物的通透性都没有可能具有生理重要性的变化。在另一组动物中，在放射状角膜切开术后不同时间间隔进行荧光光度测定，结果显示内皮荧光素通透性没有可能具有生理重要性的变化。放射状角膜切开术后一周和九至十周，房水周转率分别降低了16%和29%。
