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PERK研究患者角膜内皮通透性的评估。

The evaluation of corneal endothelial permeability in PERK study patients.

作者信息

Serle J B, Asbell P A, Obstbaum S A, Podos S M, Anh-Le N

机构信息

Department of Ophthalmology, Mount Sinai School of Medicine, City University of New York.

出版信息

Br J Ophthalmol. 1988 Apr;72(4):274-7. doi: 10.1136/bjo.72.4.274.

DOI:10.1136/bjo.72.4.274
PMID:3378023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1041431/
Abstract

Sixteen patients enrolled in the PERK study were evaluated by fluorophotometry 24 hours or six months following radial keratotomy. A comparison of eyes operated and not operated upon showed that endothelial permeability was not significantly altered 24 hours and six months after surgery. Aqueous humour flow rates and anterior chamber elimination coefficients were significantly higher 24 hours after surgery in the eyes operated on than in those not operated on. Six months after surgery there was no longer a significant difference in these factors. The increase in aqueous humour flow rates 24 hours after surgery may represent a subclinical breakdown in the blood-aqueous barrier.

摘要

16名参加PERK研究的患者在接受放射状角膜切开术后24小时或6个月时接受了荧光光度法评估。对手术眼和未手术眼的比较显示,术后24小时和6个月时内皮通透性没有明显改变。手术眼术后24小时的房水流量和前房清除系数显著高于未手术眼。术后6个月,这些因素不再有显著差异。术后24小时房水流量的增加可能代表血-房水屏障的亚临床破坏。

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1
The evaluation of corneal endothelial permeability in PERK study patients.PERK研究患者角膜内皮通透性的评估。
Br J Ophthalmol. 1988 Apr;72(4):274-7. doi: 10.1136/bjo.72.4.274.
2
Morphological and fluorophotometric analysis of the corneal endothelium after radial keratotomy.放射状角膜切开术后角膜内皮的形态学和荧光光度分析。
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Am J Ophthalmol. 1988 Jan 15;105(1):30-4. doi: 10.1016/0002-9394(88)90117-1.

本文引用的文献

1
A new surgical approach to myopia.一种治疗近视的新手术方法。
Am J Ophthalmol. 1953 Jun;36(6 1):823-9. doi: 10.1016/0002-9394(53)90183-4.
2
Bullous keratopathy after anterior-posterior radial keratotomy for myopia for myopic astigmatism.近视性散光行放射状角膜切开术后的大疱性角膜病变。
Am J Ophthalmol. 1982 May;93(5):600-6. doi: 10.1016/s0002-9394(14)77375-1.
3
Radial keratotomy. Effect on cornea and aqueous humor physiology in the rabbit.放射状角膜切开术。对兔角膜和房水生理学的影响。
Arch Ophthalmol. 1983 Mar;101(3):479-81. doi: 10.1001/archopht.1983.01040010479032.
4
Rationale for and design of the National Eye Institute Prospective Evaluation of Radial Keratotomy (PERK) Study.国家眼科研究所放射状角膜切开术前瞻性评估(PERK)研究的原理与设计
Ophthalmology. 1983 Jan;90(1):40-58. doi: 10.1016/s0161-6420(83)34603-0.
5
New methods of measuring the rate of aqueous flow in man with fluorescein.用荧光素测量人体房水流动速率的新方法。
Exp Eye Res. 1966 Jul;5(3):208-20. doi: 10.1016/s0014-4835(66)80009-x.