Perry T L, Wright J M, Hansen S
Biol Psychiatry. 1983 Jan;18(1):89-97.
A man with a chronic schizophrenia-like psychotic disorder had fasting plasma asparagine concentrations that were consistently 4 to 8 SD above the normal level. Asparagine levels were also high in his cerebrospinal fluid (CSF) and erythrocytes. Ornithine, proline, and glutamate concentrations were irregularly high in fasting plasma, and gamma-aminobutyric acid (GABA) concentrations were elevated in CSF. Whether or not these biochemical abnormalities were related to the psychotic disorder is unclear. However, increased asparagine concentrations, possibly due to an enzymatic deficiency of asparaginase, could lead to deregulation of polyamine biosynthesis and to excessive production of GABA from putrescine. These biochemical changes could in turn cause disordered brain function. A search in mentally ill patients for metabolic abnormalities involving asparagine, or other amino acids, might hasten elucidation of the biochemical basis of the schizophrenias.
一名患有慢性精神分裂症样精神障碍的男性，其空腹血浆天冬酰胺浓度始终比正常水平高出4至8个标准差。他的脑脊液（CSF）和红细胞中的天冬酰胺水平也很高。空腹血浆中的鸟氨酸、脯氨酸和谷氨酸浓度不规则地升高，脑脊液中的γ-氨基丁酸（GABA）浓度升高。这些生化异常是否与精神障碍有关尚不清楚。然而，天冬酰胺浓度升高，可能是由于天冬酰胺酶的酶缺乏，可能导致多胺生物合成失调，并导致腐胺过度产生GABA。这些生化变化进而可能导致脑功能紊乱。在精神病患者中寻找涉及天冬酰胺或其他氨基酸的代谢异常，可能会加速对精神分裂症生化基础的阐明。
