• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Effects of polyribonoinosinic acid polyribocytidylic acid and a mouse interferon preparation on cytochrome P-450-dependent monooxygenase systems in cultures of primary mouse hepatocytes.

作者信息

Renton K W, Deloria L B, Mannering G J

出版信息

Mol Pharmacol. 1978 Jul;14(4):672-81.

PMID:683177
Abstract
摘要

相似文献

1
Effects of polyribonoinosinic acid polyribocytidylic acid and a mouse interferon preparation on cytochrome P-450-dependent monooxygenase systems in cultures of primary mouse hepatocytes.聚肌苷酸-聚胞苷酸和小鼠干扰素制剂对原代小鼠肝细胞培养物中细胞色素P-450依赖的单加氧酶系统的影响。
Mol Pharmacol. 1978 Jul;14(4):672-81.
2
Effects of interferon inducing agents (polyriboinosinic acid. Polyribocytidylic acid, tilorone) on hepatic hemoproteins (cytochrome P-450, catalase, tryptophan 2,3-dioxygenase, mitochondrial cytochromes), heme metabolism and cytochrome P-450-linked monooxygenase systems.干扰素诱导剂（聚肌苷酸、聚胞苷酸、泰洛龙）对肝脏血红素蛋白（细胞色素P-450、过氧化氢酶、色氨酸2,3-双加氧酶、线粒体细胞色素）、血红素代谢及细胞色素P-450相关单加氧酶系统的影响。
Mol Pharmacol. 1979 May;15(3):698-707.
3
Kinetics of depression and recovery of murine hepatic cytochrome P-450 levels after treatment with the interferon inducer polyriboinosinic-polyribocytidylic acid.用干扰素诱导剂聚肌苷酸-聚胞苷酸治疗后小鼠肝脏细胞色素P-450水平的降低与恢复动力学
J Natl Cancer Inst. 1986 May;76(5):879-83.
4
[Changes in the monooxygenase activity of the mouse liver by the activity of high-molecular immunomodulators].
Vopr Med Khim. 1983 Nov-Dec;29(6):60-3.
5
Fetal and neonatal development of the microsomal monooxygenase system.微粒体单加氧酶系统的胎儿及新生儿发育
Drug Metab Rev. 1976;5(1):1-42.
6
Effect of interferon inducing agents (polyriboinosinic acid . polyribocytidylic acid and tilorone) on the heme turnover of hepatic cytochrome P-450.干扰素诱导剂（聚肌苷酸.聚胞苷酸和泰洛龙）对肝细胞色素P-450血红素周转的影响。
Mol Pharmacol. 1980 May;17(3):395-9.
7
Epidermis: a site of drug metabolism in neonatal rat skin. Studies on cytochrome P-450 content and mixed-function oxidase and epoxide hydrolase activity.表皮：新生大鼠皮肤中药物代谢的一个部位。细胞色素P - 450含量及混合功能氧化酶和环氧化物水解酶活性的研究。
Mol Pharmacol. 1982 Jan;21(1):239-47.
8
[Mixed function oxygenation of (plus)- and (minus)-hexobarbital and spectral changes of cytochrome P-450 in the liver of guinea pigs fed without L-ascorbic acid (author's transl)].
Hoppe Seylers Z Physiol Chem. 1973 Mar;354(3):238-42.
9
Induction of rat hepatic mixed function monooxygenases by levamisole.
Res Commun Chem Pathol Pharmacol. 1976 Oct;15(2):397-400.
10
The duration of induction and species influences the downregulation of cytochrome P450 by the interferon inducer polyinosinic acid-polycytidylic acid.诱导的持续时间和物种会影响干扰素诱导剂聚肌苷酸-聚胞苷酸对细胞色素P450的下调作用。
Drug Metab Dispos. 1995 May;23(5):536-41.

引用本文的文献

1
Upregulation of the serine palmitoyltransferase subunit SPTLC2 by endoplasmic reticulum stress inhibits the hepatic insulin response.内质网应激上调丝氨酸棕榈酰转移酶亚基 SPTLC2 抑制肝脏胰岛素反应。
Exp Mol Med. 2022 May;54(5):573-584. doi: 10.1038/s12276-022-00766-4. Epub 2022 May 5.
2
Protocol for Primary Mouse Hepatocyte Isolation.原发性小鼠肝细胞分离方案。
STAR Protoc. 2020 Aug 13;1(2):100086. doi: 10.1016/j.xpro.2020.100086. eCollection 2020 Sep 18.
3
Nck1 depletion induces activation of the PI3K/Akt pathway by attenuating PTP1B protein expression.
Nck1 耗竭通过减弱 PTP1B 蛋白表达诱导 PI3K/Akt 通路的激活。
Cell Commun Signal. 2014 Nov 14;12:71. doi: 10.1186/s12964-014-0071-9.
4
Endoplasmic reticulum stress promotes LIPIN2-dependent hepatic insulin resistance.内质网应激促进 LIPIN2 依赖性肝胰岛素抵抗。
Diabetes. 2011 Apr;60(4):1072-81. doi: 10.2337/db10-1046. Epub 2011 Feb 25.
5
Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis.自然杀伤细胞在氟烷肝炎的小鼠模型中介导严重的肝损伤。
Toxicol Sci. 2011 Apr;120(2):507-18. doi: 10.1093/toxsci/kfr005. Epub 2011 Jan 18.
6
CYP-mediated therapeutic protein-drug interactions: clinical findings, proposed mechanisms and regulatory implications.CYP 介导的治疗性蛋白-药物相互作用：临床发现、提出的机制和监管影响。
Clin Pharmacokinet. 2010 May;49(5):295-310. doi: 10.2165/11319980-000000000-00000.
7
TGFbeta induces apoptosis and EMT in primary mouse hepatocytes independently of p53, p21Cip1 or Rb status.转化生长因子β（TGFβ）可在原代小鼠肝细胞中诱导细胞凋亡和上皮-间质转化，且与p53、p21Cip1或Rb状态无关。
BMC Cancer. 2008 Jul 8;8:191. doi: 10.1186/1471-2407-8-191.
8
Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest.G1调节因子P53、P21Cip1和/或pRb的缺乏会降低肝细胞对转化生长因子β（TGFβ）细胞周期阻滞的敏感性。
BMC Cancer. 2007 Nov 19;7:215. doi: 10.1186/1471-2407-7-215.
9
Mouse liver cell culture. II. Primary culture.小鼠肝细胞培养。II. 原代培养。
In Vitro. 1981 Oct;17(10):926-34. doi: 10.1007/BF02618289.
10
Primary cultures and the levels of cytochrome P450 in hepatocytes from mouse, rat, hamster, and rabbit liver.原代培养以及来自小鼠、大鼠、仓鼠和兔肝脏的肝细胞中细胞色素P450的水平。
In Vitro. 1982 Aug;18(8):683-93. doi: 10.1007/BF02796423.