Forsander O A, Pikkarainen J A, Salaspuro M P
Hepatogastroenterology. 1983 Feb;30(1):6-8.
It has been reported that the concentration of free proline in the liver can be a limiting factor in the synthesis of hepatic collagen, and there has also been found to be a good correlation between the free proline and the amount of collagen in cirrhotic human livers. Since ethanol retards the breakdown of proline, it might be expected that ethanol-induced liver cirrhosis could be produced by the effect of ethanol on the hepatic proline level. In the present study the hepatic free proline level was increased more than three-fold by the administration of proline-rich diet to the rats used in the experiment. Administration of ethanol to the animals did not further increase the concentration of free proline of the liver. The high free proline level had no effect on the collagen formation, nor on the structure of the liver. It can therefore be assumed that the increased free proline levels observed in cirrhotic livers did not induce an increased collagen accumulation, and are a consequence of an altered proline metabolism.
据报道，肝脏中游离脯氨酸的浓度可能是肝胶原合成的一个限制因素，并且还发现游离脯氨酸与肝硬化患者肝脏中的胶原含量之间存在良好的相关性。由于乙醇会延缓脯氨酸的分解，因此可以预期乙醇诱导的肝硬化可能是乙醇对肝脏脯氨酸水平产生影响的结果。在本研究中，通过给实验所用大鼠喂食富含脯氨酸的饮食，肝脏游离脯氨酸水平增加了三倍多。给动物喂食乙醇并没有进一步提高肝脏游离脯氨酸的浓度。高游离脯氨酸水平对胶原形成和肝脏结构均无影响。因此可以假定，在肝硬化肝脏中观察到的游离脯氨酸水平升高并不会导致胶原积累增加，而是脯氨酸代谢改变的结果。
