See W R, Schlaefke M E, Loeschcke H H
J Appl Physiol Respir Environ Exerc Physiol. 1983 Feb;54(2):453-9. doi: 10.1152/jappl.1983.54.2.453.
In seven anesthetized cats central chemosensitivity was eliminated (cold block) and peripheral chemoreceptors were either stimulated or eliminated (sectioned) to test whether nonchemical vagal afferents can maintain rhythmic ventilation and to determine the relative contribution of the carotid and aortic chemoreceptors to ventilatory drive without central chemosensitivity. Elimination of all chemical afferents invariably induced apnea, whereas ventilation was reduced from 533 to 159 ml X min-1 during cold block of central chemosensitivity and to 478 ml X min-1 after sectioning both sinus nerves. Cold block with only the aortic chemoreceptors and vagal afferents intact produced apnea in four of six cases tested. Stimulation of peripheral chemoreceptors during cold block remained effective and interrupted apnea in three of the four cats with only aortic chemoreceptors intact. We conclude that the nonchemical vagal respiratory afferents alone are unable to maintain rhythmic ventilation. Respiratory rhythm generation is, under the conditions of our experiments, critically dependent on sufficient afferent input from chemical afferents. Of these, central chemosensitivity plays the major role, followed by carotid body and, least importantly, by aortic afferents.
在七只麻醉猫中，消除中枢化学敏感性（冷阻断），并刺激或消除外周化学感受器（切断），以测试非化学性迷走神经传入纤维是否能维持节律性通气，并确定在没有中枢化学敏感性的情况下，颈动脉和主动脉化学感受器对通气驱动的相对贡献。消除所有化学性传入纤维总是会诱发呼吸暂停，而在中枢化学敏感性冷阻断期间，通气量从533毫升/分钟降至159毫升/分钟，在切断双侧窦神经后降至478毫升/分钟。在六只接受测试的猫中，有四只在仅保留主动脉化学感受器和迷走神经传入纤维的冷阻断情况下出现呼吸暂停。在仅保留主动脉化学感受器的四只猫中，有三只在冷阻断期间刺激外周化学感受器仍然有效并中断了呼吸暂停。我们得出结论，仅非化学性迷走神经呼吸传入纤维无法维持节律性通气。在我们的实验条件下，呼吸节律的产生严重依赖于来自化学性传入纤维的足够传入输入。其中，中枢化学敏感性起主要作用，其次是颈动脉体，最不重要的是主动脉传入纤维。
