Iurina M S, Lavrova M F, Zenkova V A, Maksimova T S, OL'khovatova O L
Antibiotiki. 1977 Jan;22(1):22-5.
A method for isolation of cephamycins from culture fluids of actinomycetes was developed. It included the stage of effective purification of sulfocation exchange resin SDV-3 (H+) with water desorption. Further purificiation of the antibiotics was achieved with sorption on anion exchange resin and fractional precipitation. The method provided 95-96 per cent purity level of the preparations.
开发了一种从放线菌培养液中分离头孢霉素的方法。该方法包括用水解吸对磺酸阳离子交换树脂SDV - 3(H⁺)进行有效纯化的阶段。通过在阴离子交换树脂上吸附和分步沉淀实现抗生素的进一步纯化。该方法使制剂的纯度达到95 - 96%。