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组织和体液中黑色素的鉴定与表征。

Identification and characterization of melanin in tissues and body fluids.

作者信息

Sarna T, Swartz H M

出版信息

Folia Histochem Cytochem (Krakow). 1978;16(4):275-86.

PMID:217805
Abstract

A new method for the unambiguous identification of melanin in biological materials has been developed. It may also be used to differentiate between melanins from various tissues and with various properties. The method is based on the detection and characterization of the free radicals in melanin by Electron Spin Resonance Spectroscopy. Applications of this approach include the identification of microscopically undetectable melanin in amelanotic melanomas and identification of the nature of the pigment in the Dubin-Johnson Syndrome.

摘要

一种用于明确鉴定生物材料中黑色素的新方法已被开发出来。它还可用于区分来自不同组织且具有不同特性的黑色素。该方法基于通过电子自旋共振光谱法对黑色素中的自由基进行检测和表征。这种方法的应用包括鉴定无黑色素性黑色素瘤中显微镜下无法检测到的黑色素,以及鉴定杜宾 - 约翰逊综合征中色素的性质。

相似文献

1
Identification and characterization of melanin in tissues and body fluids.组织和体液中黑色素的鉴定与表征。
Folia Histochem Cytochem (Krakow). 1978;16(4):275-86.
2
Quantitative parameters of melanomas differentiation.黑色素瘤分化的定量参数。
Neoplasma. 1978;25(3):349-52.
3
Electron spin resonance and high pressure liquid chromatographic analysis of melanin in posterior choroidal melanomas.脉络膜后黑色素瘤中黑色素的电子自旋共振和高压液相色谱分析
Cancer Biochem Biophys. 1985 Jun;8(1):61-5.
4
[Electron spin resonance study of melanin in paraffin-imbedded ocular melanoma specimens].
Morphol Igazsagugyi Orv Sz. 1980 Jul;20(3):219-24.
5
Characterization of melanogenesis and morphogenesis of melanosomes by physicochemical properties of melanin and melanosomes in malignant melanoma.通过恶性黑色素瘤中黑色素和黑素小体的物理化学性质对黑素生成和黑素小体形态发生进行表征。
Cancer Res. 1984 Mar;44(3):1128-34.
6
Further evidence that the pigment in the Dubin-Johnson syndrome is not melanin.
Pigment Cell Res. 1987;1(2):69-75. doi: 10.1111/j.1600-0749.1987.tb00392.x.
7
Ultrastructural aspects of melanization of hamster Ab amelanotic melanoma in primary cell culture.仓鼠无黑色素黑色素瘤原代细胞培养中黑色素形成的超微结构特征
Acta Derm Venereol. 1986;66(6):520-3.
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Time-resolved detection of melanin free radicals quenching reactive oxygen species.黑色素自由基猝灭活性氧的时间分辨检测
J Am Chem Soc. 2005 Aug 17;127(32):11220-1. doi: 10.1021/ja052773z.
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Stable free radicals in insect cuticles: electron spin resonance spectroscopy reveals differences between melanization and sclerotization.
Arch Biochem Biophys. 2006 Sep 15;453(2):179-87. doi: 10.1016/j.abb.2006.07.001. Epub 2006 Jul 25.
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The minocycline-induced thyroid pigment and several synthetic models: identification and characterization by electron paramagnetic resonance spectroscopy.米诺环素诱导的甲状腺色素及几种合成模型:通过电子顺磁共振波谱进行鉴定和表征
J Pharmacol Exp Ther. 1993 Sep;266(3):1164-76.

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A study of free radicals in paraffin embedded and deparaffinized human heart muscle tissue using electron spin resonance (ESR).
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