La Rosa F G, Talmage D W
J Exp Med. 1983 Mar 1;157(3):898-906. doi: 10.1084/jem.157.3.898.
The lymphocytic infiltration found in multiple cultured BALB/c thyroids placed in the same C57BL/6 recipient was found to be highly correlated and the high variability between animals was not influenced by the number of lobes. It was concluded that the variable infiltration was largely due to host factors. Because a similar correlation was found between BALB/c and C3H grafts, the response to a minor antigen common to these two strains was suggested as a cause of the infiltration. When the response of C57BL/6 mice to cultured B6.C (H-2d) and BALB.B (H-2b) grafts was compared, a synergism between major and minor antigens was suggested. However, when the time of culture was increased from 48 to 60 h and the response of BALB/c and C57BL/6 mice were compared with identically cultured B6.C (H-2d) grafts, a striking difference between major and minor antigens was observed. None of 10 such grafts in C57BL/6 recipients (major antigens only) showed any infiltration, whereas 8 out of the 9 grafts in BALB/c recipients (minor antigens only) were infiltrated.
在置于同一C57BL/6受体中的多个培养的BALB/c甲状腺中发现的淋巴细胞浸润具有高度相关性，并且动物之间的高变异性不受叶数的影响。得出的结论是，可变浸润主要归因于宿主因素。由于在BALB/c和C3H移植物之间发现了类似的相关性，因此有人提出对这两个品系共有的次要抗原的反应是浸润的原因。当比较C57BL/6小鼠对培养的B6.C（H-2d）和BALB.B（H-2b）移植物的反应时，提示主要抗原和次要抗原之间存在协同作用。然而，当培养时间从48小时增加到60小时，并将BALB/c和C57BL/6小鼠对相同培养的B6.C（H-2d）移植物的反应进行比较时，观察到主要抗原和次要抗原之间存在显著差异。C57BL/6受体中的10个此类移植物（仅主要抗原）均未显示任何浸润，而BALB/c受体中的9个移植物中有8个（仅次要抗原）出现浸润。
