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移植免疫的激活:供体白细胞对甲状腺同种异体移植排斥反应的影响。

Activation of transplant immunity: effect of donor leukocytes on thyroid allograft rejection.

作者信息

Talmage D W, Dart G, Radovich J, Lafferty K J

出版信息

Science. 1976 Jan 30;191(4225):385-8. doi: 10.1126/science.1082167.

DOI:10.1126/science.1082167
PMID:1082167
Abstract

The survival of thyroid allografts in mice was prolonged by either holding the grafts in vitro culture for 20 to 27 days or by cobalt-60 irradiation of the donor 2 days before transplantation with or without the intravenous injection of colloidal carbon just before removing the thyroid from the donor. In both cases the rejection process was restored by an intravenous injection of recipients with living peritoneal exudate cells (50 to 80 percent macrophages) syngeneic to the thyroid donor.

摘要

通过将甲状腺移植物进行20至27天的体外培养,或者在移植前2天对供体进行钴 - 60照射(无论在从供体取出甲状腺前是否静脉注射胶体碳),小鼠甲状腺同种异体移植物的存活时间得以延长。在这两种情况下,通过给受体静脉注射与甲状腺供体同基因的活腹膜渗出细胞(50%至80%为巨噬细胞),排斥过程得以恢复。

相似文献

1
Activation of transplant immunity: effect of donor leukocytes on thyroid allograft rejection.移植免疫的激活:供体白细胞对甲状腺同种异体移植排斥反应的影响。
Science. 1976 Jan 30;191(4225):385-8. doi: 10.1126/science.1082167.
2
Effect of organ culture on the survival of thyroid allografts in mice.器官培养对小鼠甲状腺同种异体移植存活的影响。
Transplantation. 1976 Aug;22(2):138-49. doi: 10.1097/00007890-197608000-00009.
3
Is a specialized stimulator cell required for the induction of allograft immunity?诱导同种异体移植免疫是否需要一种特殊的刺激细胞?
Adv Exp Med Biol. 1976;66:87-93. doi: 10.1007/978-1-4613-4355-4_13.
4
Mechanism of thyroid allograft rejection.甲状腺同种异体移植排斥反应的机制。
Aust J Exp Biol Med Sci. 1976 Dec;54(6):573-86. doi: 10.1038/icb.1976.58.
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Cultured thyroid allografts induce a state of partial tolerance in adult recipient mice.培养的甲状腺同种异体移植物在成年受体小鼠中诱导出部分耐受状态。
Transplantation. 1983 Jan;35(1):62-7. doi: 10.1097/00007890-198301000-00012.
6
Enhancement of murine thyroid allograft survival after 16 to 20 hours' organ culture.器官培养16至20小时后小鼠甲状腺同种异体移植存活率的提高。
Transplantation. 1987 Mar;43(3):417-21. doi: 10.1097/00007890-198703000-00019.
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Effect of in vivo exposure to allogeneic cells upon subsequent in vitro T cell responses and upon allograft rejection.体内暴露于同种异体细胞对后续体外T细胞反应及同种异体移植排斥反应的影响。
Scand J Immunol. 1978;7(5):371-80. doi: 10.1111/j.1365-3083.1978.tb00467.x.
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Enhancement of thyroid allograft survival following organ culture. Alteration of tissue immunogenicity.器官培养后甲状腺同种异体移植存活率的提高。组织免疫原性的改变。
Transplantation. 1989 Jan;47(1):24-7. doi: 10.1097/00007890-198901000-00006.
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Antibody-mediated suppression of grafted lymphoma. III. Evaluation of the role of thymic function, non-thymus-derived lymphocytes, macrophages, platelets, and polymorphonuclear leukocytes in syngeneic and allogeneic hosts.抗体介导的移植性淋巴瘤抑制作用。III. 胸腺功能、非胸腺来源淋巴细胞、巨噬细胞、血小板和多形核白细胞在同基因和异基因宿主中的作用评估
J Immunol. 1975 Apr;114(4):1255-63.
10
Thyroid allograft immunogenicity is reduced after a period in organ culture.甲状腺同种异体移植物在器官培养一段时间后免疫原性降低。
Science. 1975 Apr 18;188(4185):259-61. doi: 10.1126/science.1118726.

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