Talmage D W, Dart G, Radovich J, Lafferty K J
Science. 1976 Jan 30;191(4225):385-8. doi: 10.1126/science.1082167.
The survival of thyroid allografts in mice was prolonged by either holding the grafts in vitro culture for 20 to 27 days or by cobalt-60 irradiation of the donor 2 days before transplantation with or without the intravenous injection of colloidal carbon just before removing the thyroid from the donor. In both cases the rejection process was restored by an intravenous injection of recipients with living peritoneal exudate cells (50 to 80 percent macrophages) syngeneic to the thyroid donor.
通过将甲状腺移植物进行20至27天的体外培养,或者在移植前2天对供体进行钴 - 60照射(无论在从供体取出甲状腺前是否静脉注射胶体碳),小鼠甲状腺同种异体移植物的存活时间得以延长。在这两种情况下,通过给受体静脉注射与甲状腺供体同基因的活腹膜渗出细胞(50%至80%为巨噬细胞),排斥过程得以恢复。