Elo J, Tallgren L G, Alfthan O, Sarna S
J Urol. 1983 Feb;129(2):343-6. doi: 10.1016/s0022-5347(17)52089-3.
We followed 40 girls who had undergone antireflux surgery (the Politano-Leadbetter technique) at the mean age of 5.2 years until they reached a mean age of 9.5 years. Each girl was matched with a control. The pairs were matched for age at the onset of urinary tract infections and time of operation or selection, number as well as grade (1 to 3) of severity of the preoperative episodes and grade (II to IV) of reflux. Followup time for each member of the pair was identical. Postoperatively, the incidence of pyelonephritic urinary tract infection episodes (grade 3) was significantly less (p less than 0.01) among the operated than the nonoperated cases (9 versus 29), while the number of symptomatic lower urinary tract infections (grade 2) was virtually the same (14 versus 19) in both groups. The operated cases had more asymptomatic bacteriuria (26 versus 12 episodes) so that the total numbers of episodes of bacteriuria (grades 1 through 3) were similar in both groups. Antireflux surgery did not prevent the progression of pyelonephritic renal scarring, which continued equally in operated and nonoperated cases.
我们对40名平均年龄5.2岁时接受抗反流手术（波利塔诺-利德贝特技术）的女孩进行了跟踪，直至她们达到平均年龄9.5岁。每个女孩都与一名对照者匹配。配对时考虑了尿路感染发作时的年龄、手术或入选时间、术前发作的次数以及严重程度分级（1至3级）和反流分级（II至IV级）。配对的每个成员的随访时间相同。术后，接受手术的病例中肾盂肾炎性尿路感染发作（3级）的发生率显著低于未手术病例（9例对29例，p<0.01），而两组有症状的下尿路感染（2级）的数量实际上相同（14例对19例）。接受手术的病例无症状菌尿更多（26次发作对12次发作），因此两组菌尿发作总数（1至3级）相似。抗反流手术未能阻止肾盂肾炎性肾瘢痕形成的进展，手术组和未手术组的进展情况相同。
