16种芳香胺和偶氮衍生物在体内诱导姐妹染色单体交换的能力与致癌潜能之间缺乏相关性。

Lack of correlation between the capability of inducing sister-chromatid exchanges in vivo and carcinogenic potency, for 16 aromatic amines and azo derivatives.

作者信息

Parodi S, Zunino A, Ottaggio L, De Ferrari M, Santi L

出版信息

Mutat Res. 1983 Mar;108(1-3):225-38. doi: 10.1016/0027-5107(83)90122-7.

Abstract

16 aromatic amines and azo derivatives were studied. They were: benzidine; 2-acetylaminofluorene; 3'-methyl-p-dimethylaminoazobenzene; o-aminoazotoluene; p-dimethylaminoazobenzene; 2,4-diaminotoluene; 4,4'-oxydianiline; 2,4-diaminoanisole; 4,4'-methylenedianiline; 2-naphthylamine; auramine O; rhodamine B; ponceau MX; 1-naphthylamine; p-aminoazobenzene and aniline. Carcinogenic potency and potency in inducing sister-chromatid exchanges (SCEs) in vivo were compared. SCEs were absolutely not correlated with carcinogenic potency. A lack of correlation was also found with mutagenicity in the Ames test. On the contrary, a statistically significant correlation existed between DNA damage and SCEs.

摘要

对16种芳香胺和偶氮衍生物进行了研究。它们分别是：联苯胺；2-乙酰氨基芴；3'-甲基-对二甲氨基偶氮苯；邻氨基偶氮甲苯；对二甲氨基偶氮苯；2,4-二氨基甲苯；4,4'-氧代二苯胺；2,4-二氨基苯甲醚；4,4'-亚甲基二苯胺；2-萘胺；金胺O；罗丹明B；丽春红MX；1-萘胺；对氨基偶氮苯和苯胺。比较了它们在体内的致癌效力和诱导姐妹染色单体交换（SCE）的效力。SCE与致癌效力绝对不相关。在艾姆斯试验中也发现与致突变性缺乏相关性。相反，DNA损伤与SCE之间存在统计学上的显著相关性。