Parodi S, Zunino A, Ottaggio L, De Ferrari M, Santi L
Mutat Res. 1983 Mar;108(1-3):225-38. doi: 10.1016/0027-5107(83)90122-7.
16 aromatic amines and azo derivatives were studied. They were: benzidine; 2-acetylaminofluorene; 3'-methyl-p-dimethylaminoazobenzene; o-aminoazotoluene; p-dimethylaminoazobenzene; 2,4-diaminotoluene; 4,4'-oxydianiline; 2,4-diaminoanisole; 4,4'-methylenedianiline; 2-naphthylamine; auramine O; rhodamine B; ponceau MX; 1-naphthylamine; p-aminoazobenzene and aniline. Carcinogenic potency and potency in inducing sister-chromatid exchanges (SCEs) in vivo were compared. SCEs were absolutely not correlated with carcinogenic potency. A lack of correlation was also found with mutagenicity in the Ames test. On the contrary, a statistically significant correlation existed between DNA damage and SCEs.
对16种芳香胺和偶氮衍生物进行了研究。它们分别是：联苯胺；2-乙酰氨基芴；3'-甲基-对二甲氨基偶氮苯；邻氨基偶氮甲苯；对二甲氨基偶氮苯；2,4-二氨基甲苯；4,4'-氧代二苯胺；2,4-二氨基苯甲醚；4,4'-亚甲基二苯胺；2-萘胺；金胺O；罗丹明B；丽春红MX；1-萘胺；对氨基偶氮苯和苯胺。比较了它们在体内的致癌效力和诱导姐妹染色单体交换（SCE）的效力。SCE与致癌效力绝对不相关。在艾姆斯试验中也发现与致突变性缺乏相关性。相反，DNA损伤与SCE之间存在统计学上的显著相关性。
