Milutinovic J, Fialkow P J, Agodoa L Y, Phillips L A, Bryant J I
Obstet Gynecol. 1983 May;61(5):566-70.
Fertility and pregnancy complications were assessed in 137 women at risk of having inherited the gene for autosomal dominant polycystic kidney disease. Seventy-six (55%) of these subjects were found to have polycystic kidney disease (multiple renal cysts). The remaining 61 women served as controls. The prevalence of fertility, spontaneous abortion, stillbirth, and symptoms consistent with urinary tract infection were not different in the two groups. However, the frequency of hypertension first diagnosed during pregnancy (with or without preeclampsia or eclampsia) and the frequency of pregnancy-unrelated hypertension were higher in women with polycystic kidney disease. No evidence was found that pregnancy had an adverse effect on the natural course of polycystic kidney disease. The incidence of renal failure was not higher in women with polycystic kidney disease who had three or more pregnancies than in women of similar ages who had two, one, or no pregnancies.
对137名有遗传常染色体显性多囊肾病基因风险的女性进行了生育能力和妊娠并发症评估。其中76名（55%）受试者被发现患有多囊肾病（多个肾囊肿）。其余61名女性作为对照。两组在生育能力、自然流产、死产以及与尿路感染相符的症状发生率方面并无差异。然而，多囊肾病女性在孕期首次诊断出高血压（伴有或不伴有先兆子痫或子痫）的频率以及与妊娠无关的高血压频率更高。未发现有证据表明妊娠会对多囊肾病的自然病程产生不利影响。有多囊肾病且怀孕三次或以上的女性肾衰竭发生率并不高于年龄相仿但怀孕两次、一次或未怀孕的女性。
