Isaev E I, Ergashova M Zh, Salikhodzheva D S, Turakulov Ia Kh
Probl Endokrinol (Mosk). 1983 Jan-Feb;29(1):67-71.
Thin-layer chromatography on silica gel was used to identify individual gangliosides in the rat brain, cardiac, renal, spleen, pancreatic and skeletal muscles in health and to measure the content of sialic acid in the above organs. A dramatic decrease in mono-, di-, tri- and polysialoganglioside levels was seen in tissues of rats with alloxan diabetes. The data obtained indicate that insulin reception disorders may be provoked by the reduced content of acidic glycolipids in plasma membranes.
采用硅胶薄层层析法对健康大鼠脑、心脏、肾脏、脾脏、胰腺及骨骼肌中的单个神经节苷脂进行鉴定，并测定上述器官中唾液酸的含量。在四氧嘧啶糖尿病大鼠的组织中，单唾液酸、二唾液酸、三唾液酸和多唾液酸神经节苷脂水平显著降低。所得数据表明，质膜中酸性糖脂含量降低可能引发胰岛素受体紊乱。
