Christodoulou G N, Alevizos B H, Konstantakakis E
Psychother Psychosom. 1983;39(1):55-62. doi: 10.1159/000287721.
34 male peptic ulcer patients were compared to (a) a group of 37 healthy controls and (b) a group of 36 hospitalized controls suffering from illnesses unrelated to the gastrointestinal tract. Patients and controls were submitted to the Eysenck personality inventory, Foulds' hostility questionnaire, Langner's 22-item questionnaire, the Hopkins symptom checklist, Zung's self-rating anxiety scale, Spielberger's state-trait anxiety inventory, Zung's and Beck's rating scales for depression, and the 43-item life event inventory by Holmes and Rahe. All patients suffered from duodenal ulcer. The parameters that differentiated to a statistically significant degree the peptic ulcer patients from either one or both groups of controls were: (a) neuroticism, (b) trait and state anxiety, (c) guilt, (d) general psychopathology, and (e) stressful life events. Additionally, more than 50% of patients had at least one first-degree relative with peptic ulcer. These observations indicate that psychopathological, psychosocial, characterological and hereditary factors are important pathogenetic contributors in peptic ulcer.
34名男性消化性溃疡患者与（a）一组37名健康对照者以及（b）一组36名患有与胃肠道无关疾病的住院对照者进行了比较。患者和对照者均接受了艾森克人格问卷、福尔兹敌意问卷、朗纳22项问卷、霍普金斯症状清单、zung自评焦虑量表、斯皮尔伯格状态-特质焦虑量表、zung和贝克抑郁评定量表以及霍姆斯和拉赫的43项生活事件清单测试。所有患者均患有十二指肠溃疡。在统计学上能将消化性溃疡患者与一组或两组对照者显著区分开来的参数包括：（a）神经质，（b）特质焦虑和状态焦虑，（c）内疚感，（d）一般精神病理学，以及（e）应激性生活事件。此外，超过50%的患者至少有一位患有消化性溃疡的一级亲属。这些观察结果表明，心理病理学、心理社会、性格学和遗传因素是消化性溃疡重要的发病因素。
