Al-Mashat R R, Taylor D J
Vet Rec. 1983 Jan 15;112(3):54-8. doi: 10.1136/vr.112.3.54.
Pure cultures of an isolate of Campylobacter fetus subspecies intestinalis obtained from the congested small intestinal mucosa of a two-week-old calf were used to infect three milk-fed calves and three ruminating calves in two separate controlled experiments. Inoculated animals all developed clinical signs which included fever (to 40 degrees C) and diarrhoea with excess clear mucus containing occasional spots of blood. C fetus subspecies intestinalis was isolated from the faeces of all infected animals in the two experiments but not from those of the five control animals. Changes in the enteric tract were most marked in the ileum which was thickened and mildly inflamed with accumulations of lymphoid cells and crypts filled with inflammatory cells in all six infected animals. The mesenteric lymph nodes were pale and enlarged. C fetus subspecies intestinalis was recovered from the jejunum, ileum, caecum and colon of the infected animals and less frequently from the abomasum, mesenteric lymph nodes, liver and gall bladder. It was never isolated from the control animals. Antibody to the inocular strain of C fetus subspecies intestinalis was demonstrated, at titres of at least 1 in 320, in the serum of all inoculated animals and was absent from all the control sera. The findings were considered to indicate that C fetus subspecies intestinalis caused the syndrome described above and that the syndrome produced differed only in minor details from that produced in calves by infection with C jejuni.
从一头两周龄小牛充血的小肠黏膜中分离出胎儿弯曲菌小肠亚种的纯培养物，在两项独立的对照实验中用于感染三头以奶为食的小牛和三头反刍小牛。接种动物均出现临床症状，包括发热（体温达40摄氏度）和腹泻，粪便中有大量清亮黏液，偶尔带血斑。在两项实验中，均从所有感染动物的粪便中分离出胎儿弯曲菌小肠亚种，而五头对照动物的粪便中未分离到。肠道变化在回肠最为明显，所有六头感染动物的回肠均增厚且轻度发炎，有淋巴细胞聚集，隐窝充满炎性细胞。肠系膜淋巴结苍白且肿大。在感染动物的空肠、回肠、盲肠和结肠中均分离到胎儿弯曲菌小肠亚种，在皱胃、肠系膜淋巴结、肝脏和胆囊中较少分离到。对照动物中从未分离到。所有接种动物的血清中均检测到针对接种的胎儿弯曲菌小肠亚种菌株的抗体，效价至少为1:320，而所有对照血清中均未检测到。这些结果被认为表明胎儿弯曲菌小肠亚种引起了上述综合征，且该综合征与空肠弯曲菌感染小牛所产生的综合征仅在细微之处有所不同。
