Rolando M, Refojo M F, Kenyon K R
Arch Ophthalmol. 1983 Apr;101(4):557-8. doi: 10.1001/archopht.1983.01040010557003.
The terms dry eye and keratoconjunctivitis sicca (KCS) imply a condition of highly reduced or absent tear film that often is not clinically demonstrable despite the presence of other signs and symptoms. In 52 patients with KCS symptoms, either with or without tear volume reduction as measured by Schirmer's basic secretion test, we found a statistically significant increase in water evaporation rate from the tear film when compared with normal subjects. Such an increased evaporation rate might account for the tear hypertonicity known to be associated with KCS and postulated to be responsible for ocular surface damage. Thus, we propose to identify this group of paradoxically wet "dry eyes" as a "syndrome of increased tear evaporation", which better describes the pathogenesis of the ocular condition.
干眼和角结膜干燥症（KCS）这两个术语意味着泪膜高度减少或缺失的一种状况，尽管存在其他体征和症状，但这种状况在临床上往往无法得到证实。在52例有KCS症状的患者中，无论其通过Schirmer基础分泌试验测得的泪液量是否减少，我们发现与正常受试者相比，泪膜的水分蒸发率有统计学意义的增加。这种增加的蒸发率可能解释了已知与KCS相关且被认为是眼表损伤原因的泪液高渗性。因此，我们建议将这组看似湿润的“干眼”识别为“泪液蒸发增加综合征”，这能更好地描述眼部疾病的发病机制。
