Bartsch G, Baumgartner U, Rohr H P
Pathol Res Pract. 1978 Jul;162(3):291-300. doi: 10.1016/S0344-0338(78)80044-2.
The ultrastructure of SHR (Spontaneously Hypertensive Rats) fasciculata cells was compared descriptively and quantitatively with that of nonstimulated fasciculata cells of Wistar rats using sterological methods. The volume and surface densities are expressed per cm3 of cytoplasm. The smooth endoplasmic reticulum in the SHR was significantly increased compared to the control animals (surface density : 28%, volume density: 35%). Mitochondria volume remained unchanged although the inner mitochondrial membranes were significantly reduced (37%). An attempt was made to draw up a relation between sterological and biochemical data of steroid synthesis within the fasciculata cell. A genetically determined enzymatic defect in the early steps of the transformation of cholesterol to pregnenolone may exist at the level of the inner mitochondrial membrane. Whether this altered steroid metabolism is important to the etiology of hypertension in the SHR requires further investigation.
采用体视学方法，对自发性高血压大鼠（SHR）束状带细胞的超微结构与Wistar大鼠未受刺激的束状带细胞进行了描述性和定量比较。体积密度和表面密度以每立方厘米细胞质表示。与对照动物相比，SHR中滑面内质网显著增加（表面密度：28%，体积密度：35%）。线粒体体积保持不变，尽管线粒体内膜显著减少（37%）。试图建立束状带细胞内甾体合成的体视学数据与生化数据之间的关系。在线粒体内膜水平可能存在胆固醇转化为孕烯醇酮早期步骤中由基因决定的酶缺陷。这种改变的甾体代谢是否对SHR高血压的病因学很重要，还需要进一步研究。
