Radl J, Punt Y A, van den Enden-Vieveen M H, Bentvelzen P A, Bakkus M H, van den Akker T W, Benner R
TNO Institute for Experimental Gerontology, Rijswijk, The Netherlands.
Br J Cancer. 1990 Feb;61(2):276-8. doi: 10.1038/bjc.1990.51.
Consistent chromosomal translocations involving the c-myc cellular oncogene and one of the three immunoglobin loci are typical for human Burkitt's lymphoma, induced mouse plasmacytoma (MPC) and spontaneously arising rat immunocytoma (RIC). Another plasma cell malignancy, multiple myeloma (MM), arising spontaneously in the ageing C57BL/KaLwRij mice, was investigated in order to see whether the MM cells contain c-myc abnormalities of the MPC or RIC type. Rearrangement of the c-myc oncogene was found in the bone marrow cells only in 5T2 MM transplantation line in a mouse of the 24th generation and in none of the seven other MM of the 5T series which were of earlier generations. Since the mouse 5T MM resembles the human MM very closely, including the absence of consistent structural c-myc oncogene abnormalities, it can serve as a useful experimental model for studies on the aetiopathogenesis of this disease.
涉及c-myc细胞癌基因和三个免疫球蛋白基因座之一的一致性染色体易位，在人类伯基特淋巴瘤、诱导性小鼠浆细胞瘤（MPC）和自发性大鼠免疫细胞瘤（RIC）中很典型。另一种浆细胞恶性肿瘤，即老龄C57BL/KaLwRij小鼠中自发产生的多发性骨髓瘤（MM），为了观察MM细胞是否含有MPC或RIC类型的c-myc异常而进行了研究。仅在第24代小鼠的5T2 MM移植系的骨髓细胞中发现了c-myc癌基因重排，而在5T系列的其他七个较早代的MM中均未发现。由于小鼠5T MM与人类MM非常相似，包括不存在一致的结构性c-myc癌基因异常，因此它可作为研究该疾病病因发病机制的有用实验模型。
