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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Kobayashi J, Nakamura H, Hirata Y, Ohizumi Y

Comp Biochem Physiol B. 1983;74(3):381-4. doi: 10.1016/0305-0491(83)90198-0.

Tessulatoxin, a powerful vasoactive protein from the marine snail Conus tessulatus, has been purified by affinity and electrofocusing chromatography. 2. The purified protein is almost homogeneous on slab gel electrophoresis. 3. The molecular weight of tessulatoxin is 26,000: the lethal dose for the fish Rhodeus ocellatus smithi is 1 microgram/g. 4. This toxic protein (10(-7) approximately 5 X 10(-7) g/ml) causes a marked contraction of the rabbit isolated aorta, which is inhibited by verapamil (10(-6) M).

Tessulatoxin是一种从海蜗牛Conus tessulatus中提取的强效血管活性蛋白，已通过亲和色谱和等电聚焦色谱法进行了纯化。2. 纯化后的蛋白质在平板凝胶电泳上几乎呈均一状态。3. Tessulatoxin的分子量为26,000：对鱼类中华鳑鲏的致死剂量为1微克/克。4. 这种有毒蛋白质（10^(-7)约5×10^(-7)克/毫升）可使兔离体主动脉显著收缩，而维拉帕米（10^(-6)M）可抑制这种收缩。

Kobayashi J, Nakamura H, Hirata Y, Ohizumi Y

Comp Biochem Physiol B. 1983;74(3):381-4. doi: 10.1016/0305-0491(83)90198-0.

Tessulatoxin, a powerful vasoactive protein from the marine snail Conus tessulatus, has been purified by affinity and electrofocusing chromatography. 2. The purified protein is almost homogeneous on slab gel electrophoresis. 3. The molecular weight of tessulatoxin is 26,000: the lethal dose for the fish Rhodeus ocellatus smithi is 1 microgram/g. 4. This toxic protein (10(-7) approximately 5 X 10(-7) g/ml) causes a marked contraction of the rabbit isolated aorta, which is inhibited by verapamil (10(-6) M).

Tessulatoxin是一种从海蜗牛Conus tessulatus中提取的强效血管活性蛋白，已通过亲和色谱和等电聚焦色谱法进行了纯化。2. 纯化后的蛋白质在平板凝胶电泳上几乎呈均一状态。3. Tessulatoxin的分子量为26,000：对鱼类中华鳑鲏的致死剂量为1微克/克。4. 这种有毒蛋白质（10^(-7)约5×10^(-7)克/毫升）可使兔离体主动脉显著收缩，而维拉帕米（10^(-6)M）可抑制这种收缩。