Kobayashi J, Nakamura H, Hirata Y, Ohizumi Y
Life Sci. 1982 Sep 13;31(11):1085-91. doi: 10.1016/0024-3205(82)90081-9.
Eburnetoxin, a powerful vasoactive protein has been isolated from the venom of the marine snail Conus eburneus, monitored by the contractile effect to the rabbit aorta. The molecular weight was estimated to be 28,000 by gel permeation chromatography and slab gel electrophoresis. The purified protein was electrophoretically homogeneous. The toxin at concentrations above 3 X 10(-7) g/ml elicited a marked contractile response of aorta, which was inhibited by verapamil (10(-6) M). The minimum lethal dose in the fish Rhodeus ocellatus smithi was 1 microgram/g body weight.
埃布纳毒素是一种强效血管活性蛋白，已从海蜗牛白瓷芋螺的毒液中分离出来，通过对兔主动脉的收缩效应进行监测。通过凝胶渗透色谱法和平板凝胶电泳估计其分子量为28,000。纯化后的蛋白在电泳上是均一的。浓度高于3×10⁻⁷ g/ml的毒素会引起主动脉明显的收缩反应，而维拉帕米（10⁻⁶ M）可抑制这种反应。在鱼类圆尾斗鱼中，最小致死剂量为1微克/克体重。
