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Pharmacokinetic predictions based on a variable dosage frequency in chronic treatment.

作者信息

Messori A, Donati-Cori G, Tendi E

出版信息

Drug Intell Clin Pharm. 1983 Apr;17(4):290-2. doi: 10.1177/106002808301700413.

Abstract

After repeated intramuscular or oral administration, plasma drug levels are predicted by using a programmable calculator. Predictions are based on a one-compartment, open model with first-order absorption. The actual times of dosing are considered, so that the assumption of a constant dosing interval is not required. A brief analysis of the pharmacokinetic consequences that may result from a variable dosage frequency is presented.

摘要

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