Rocchelli B, Poloni M, Mazzarello P, Delodovici M
Eur Neurol. 1983;22(1):35-42. doi: 10.1159/000115534.
The IgG oligoclonal bands in CSF can be found in high percentage of MS patients but the existence of a limited number of cases with CSF normal IgG profile is known as well. In the present study 63 out of 70 patients with definite MS and 24 out of 35 with probable MS had oligoclonal bands in the CSF at the isoelectric focusing examination. The 18 patients with normal CSF IgG pattern did not show any statistically significant difference as concerns the age at onset and the duration of the disease, the functional disability, the course of the disease and the quantitative CSF parameters (IgG index, IgG synthesis and serum/CSF albumin quotient). The oligoclonal pattern does not seem of value to discriminate different groups of MS patients but it remains essentially of great diagnostic importance in this disease.
脑脊液中的IgG寡克隆带在高比例的多发性硬化症（MS）患者中可以检测到，但也有少数病例脑脊液中IgG谱正常。在本研究中，70例确诊为MS的患者中有63例，35例可能为MS的患者中有24例，在等电聚焦检查中脑脊液出现寡克隆带。18例脑脊液IgG模式正常的患者在发病年龄、病程、功能残疾程度、疾病进程以及脑脊液定量参数（IgG指数、IgG合成及血清/脑脊液白蛋白商）方面均未显示出任何统计学上的显著差异。寡克隆模式似乎对区分不同组别的MS患者没有价值，但在该疾病中其仍具有重要的诊断意义。
