Jerntorp P, Almér L O, Ohlin H, Wåhlin-Boll E, Melander A
Eur J Clin Pharmacol. 1983;24(2):237-42. doi: 10.1007/BF00613824.
The chlorpropamide-alcohol flush (CPAF) phenomenon was quantitatively related to blood levels of acetaldehyde and chlorpropamide in 105 Type II diabetics, of whom 74 had not previously taken the drug and 31 were on chronic treatment. Standardized skin temperature recordings were made with a sensitive probe. Plasma ethanol and acetaldehyde concentrations were determined by gas chromatography, and those of chlorpropamide by high-pressure liquid chromatography. There were significant positive correlations between plasma acetaldehyde and the skin temperature increase, between plasma chlorpropamide and plasma acetaldehyde, and between plasma chlorpropamide and the skin temperature increase. CPAF-positive patients became CPAF-negative and vice versa following reduction and increase, respectively, in the dose of chlorpropamide. Thus, the CPAF reaction is a consequence of chlorpropamide inhibition of the oxidation of ethanol-generated acetaldehyde, and it appears that the plasma concentration of chlorpropamide is critical. It remains an open question whether the CPAF test has any prognostic value.
在105例II型糖尿病患者中，氯磺丙脲-乙醇潮红（CPAF）现象与乙醛和氯磺丙脲的血药浓度存在定量关系，其中74例此前未服用过该药物，31例正在接受长期治疗。使用灵敏探头进行标准化皮肤温度记录。通过气相色谱法测定血浆乙醇和乙醛浓度，通过高压液相色谱法测定氯磺丙脲浓度。血浆乙醛与皮肤温度升高之间、血浆氯磺丙脲与血浆乙醛之间以及血浆氯磺丙脲与皮肤温度升高之间均存在显著正相关。分别降低和增加氯磺丙脲剂量后，CPAF阳性患者变为CPAF阴性，反之亦然。因此，CPAF反应是氯磺丙脲抑制乙醇生成的乙醛氧化的结果，并且似乎氯磺丙脲的血浆浓度至关重要。CPAF试验是否具有任何预后价值仍是一个悬而未决的问题。
