Barnett A H, Gonzalez-Auvert C, Pyke D A, Saunders J B, Williams R, Dickenson C J, Rawlins M D
Br Med J (Clin Res Ed). 1981 Oct 10;283(6297):939-41. doi: 10.1136/bmj.283.6297.939.
To test the suggestion that chlorpropamide-alcohol flushing (CPAF) resembles the disulfiram effect and might be mediated by acetaldehyde, the initial metabolite of alcohol, blood concentrations of acetaldehyde were measured after a drink of alcohol in controls and diabetics positive and negative for CPAF. The CPAF-positive diabetics had significantly greater blood acetaldehyde concentrations after alcohol than the CPAF-negative diabetics both with a single dose of chlorpropamide and after two weeks' chlorpropamide treatment. Concentrations in the CPAF-positive group after chlorpropamide were also significantly greater than after a placebo tablet. There was also a clear separation in the increase in facial temperature after two weeks of chlorpropamide between the CPAF-positive and CPAF-negative groups (although there was some overlap after a single tablet). There was no difference in plasma chlorpropamide or alcohol concentrations between CPAF-positive and CPAF-negative diabetics. These findings show that CPAF is distinct from alcohol flushing and that the acetaldehyde concentration in the blood provides an objective measure of CPAF. The difference between flushing and non-flushing diabetics cannot be accounted for by differences in blood concentrations of chlorpropamide or alcohol.
为了验证氯磺丙脲 - 酒精潮红（CPAF）类似于双硫仑样反应且可能由酒精的初始代谢产物乙醛介导这一观点，在对照组以及CPAF阳性和阴性的糖尿病患者饮酒后，测量了他们血液中的乙醛浓度。无论是单次服用氯磺丙脲还是经过两周氯磺丙脲治疗后，CPAF阳性的糖尿病患者饮酒后血液中的乙醛浓度都显著高于CPAF阴性的糖尿病患者。氯磺丙脲治疗后，CPAF阳性组的乙醛浓度也显著高于服用安慰剂片后的浓度。在服用氯磺丙脲两周后，CPAF阳性组和CPAF阴性组面部温度升高情况也有明显差异（尽管服用单片药物后存在一定重叠）。CPAF阳性和阴性的糖尿病患者血浆中氯磺丙脲或酒精浓度没有差异。这些发现表明，CPAF与酒精性潮红不同，血液中的乙醛浓度为CPAF提供了一种客观指标。潮红和不潮红的糖尿病患者之间的差异不能用氯磺丙脲或酒精血液浓度的差异来解释。
