氯磺丙脲-乙醇潮红：一种与糖尿病相关的显性遗传性状。
Chlorpropamide-alcohol flushing: a dominantly inherited trait associated with diabetes.
作者信息
Leslie R D, Pyke D A
出版信息
Br Med J. 1978 Dec 2;2(6151):1519-21. doi: 10.1136/bmj.2.6151.1519.
A simple test was devised to identify people susceptible to chlorpropamide-alcohol flushing (CPAF). Subjects were given a placebo tablet, followed by sherry 12 and 36 hours later. They then received a chlorpropamide tablet and sherry again after 12 and 36 hours. This single-dose challenge test was given to non-insulin-dependent diabetics, insulin-dependent diabetics, and normal subjects. CPAF was common in the non-insulin-dependent diabetics but rare in the other groups. When the test was used in identical twins and families of affected subjects CPAF appeared to be a dominantly inherited trait. We conclude that facial flushing after alcohol in people taking chlorpropamide is related to non-insulin-dependent diabetes, especially when there is a strong family history of diabetes, but not to insulin-dependent diabetes. It is a dominantly inherited trait.
设计了一项简单测试来识别易患氯磺丙脲-酒精潮红（CPAF）的人群。受试者先服用一片安慰剂，12小时和36小时后分别饮用雪利酒。然后，他们在12小时和36小时后再次服用氯磺丙脲片并饮用雪利酒。这项单剂量激发试验应用于非胰岛素依赖型糖尿病患者、胰岛素依赖型糖尿病患者和正常受试者。CPAF在非胰岛素依赖型糖尿病患者中很常见，但在其他组中很少见。当该测试应用于同卵双胞胎和患病受试者的家族成员时，CPAF似乎是一种显性遗传性状。我们得出结论，服用氯磺丙脲的人饮酒后面部潮红与非胰岛素依赖型糖尿病有关，尤其是当有强烈的糖尿病家族史时，但与胰岛素依赖型糖尿病无关。它是一种显性遗传性状。
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