某些2-氨基乙磺酸（牛磺酸）衍生物的抗惊厥活性。
Anticonvulsant activity of some 2-aminoethanesulphonic acid (taurine) derivatives.
作者信息
Oja S S, Kontro P, Lindén I B, Gothóni G
出版信息
Eur J Pharmacol. 1983 Feb 18;87(2-3):191-8. doi: 10.1016/0014-2999(83)90329-1.
A number of aliphatic 2-aminoethanesulphonic acid (taurine) derivatives were tested for their anticonvulsant activity in maximal electroshock seizure and pentylenetetrazole seizure threshold tests in mice. Certain piperidino, benzamido, phthalimido and phenylsuccinylimido derivatives were effective. Phthalimidoethanesulphon-N-methylamide, which inhibited the binding of both taurine and GABA to isolated synaptic membranes, appeared the best anticonvulsant among the derivatives tested.
在小鼠的最大电休克惊厥和戊四氮惊厥阈值试验中，对多种脂肪族2-氨基乙烷磺酸（牛磺酸）衍生物的抗惊厥活性进行了测试。某些哌啶基、苯甲酰胺基、邻苯二甲酰亚胺基和苯基琥珀酰亚胺基衍生物具有活性。邻苯二甲酰亚胺乙烷磺-N-甲酰胺能抑制牛磺酸和γ-氨基丁酸与分离突触膜的结合，在所测试的衍生物中似乎是最佳抗惊厥剂。
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