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牛磺酸作为大脑中的渗透压调节剂和神经调节剂。

Taurine as osmoregulator and neuromodulator in the brain.

作者信息

Oja S S, Saransaari P

机构信息

Tampere Brain Research Center, University of Tampere Medical School, Finland.

出版信息

Metab Brain Dis. 1996 Jun;11(2):153-64. doi: 10.1007/BF02069502.

DOI:10.1007/BF02069502
PMID:8776717
Abstract

Taurine has been assumed to function as an osmoregulator and neuromodulator in the brain. The pertinent studies are now reviewed in an attempt to formulate a unifying hypothesis as to how taurine could simultaneously act in both roles. Neuromodulatory actions of taurine may also underlie its protective effects against neuronal overexcitation and glutamate agonist-induced neurotoxicity.

摘要

牛磺酸被认为在大脑中起着渗透调节和神经调节的作用。现将相关研究进行综述,以试图就牛磺酸如何能同时发挥这两种作用形成一个统一的假说。牛磺酸的神经调节作用也可能是其对神经元过度兴奋和谷氨酸激动剂诱导的神经毒性具有保护作用的基础。

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本文引用的文献

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Actions of taurine on the GABA-benzodiazepine receptor complex solubilized from rat brain.牛磺酸对从大鼠脑中溶解出的γ-氨基丁酸-苯二氮䓬受体复合物的作用。
Neurochem Int. 1987;11(1):113-7. doi: 10.1016/0197-0186(87)90157-4.
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Anticonvulsant activity of 2-phthalimidoethanesulphonamides: New derivatives of taurine.
Neurochem Int. 1983;5(3):319-24. doi: 10.1016/0197-0186(83)90034-7.
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The excitation and depression of spinal neurones by structurally related amino acids.结构相关氨基酸对脊髓神经元的兴奋和抑制作用。
长期使用安非他命导致组织中谷氨酸和谷氨酰胺能神经递质调质牛磺酸和犬尿氨酸水平的破坏。
Psychopharmacology (Berl). 2024 Jul;241(7):1387-1398. doi: 10.1007/s00213-024-06570-4. Epub 2024 Mar 14.
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Effects of Taurine in Mice and Zebrafish Behavioral Assays With Translational Relevance to Schizophrenia.牛磺酸对具有精神分裂症转化相关性的小鼠和斑马鱼行为分析的影响。
Int J Neuropsychopharmacol. 2023 Feb 14;26(2):125-136. doi: 10.1093/ijnp/pyac073.
5
Taurine mitigates cirrhosis-associated heart injury through mitochondrial-dependent and antioxidative mechanisms.牛磺酸通过线粒体依赖性和抗氧化机制减轻肝硬化相关性心脏损伤。
Clin Exp Hepatol. 2020 Sep;6(3):207-219. doi: 10.5114/ceh.2020.99513. Epub 2020 Sep 30.
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Metabolomics approach revealed robust changes in amino acid and biogenic amine signatures in patients with schizophrenia in the early course of the disease.代谢组学方法揭示了疾病早期精神分裂症患者的氨基酸和生物胺特征存在显著变化。
Sci Rep. 2020 Aug 19;10(1):13983. doi: 10.1038/s41598-020-71014-w.
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Profiling of Amino Acids and Their Derivatives Biogenic Amines Before and After Antipsychotic Treatment in First-Episode Psychosis.首发精神病患者抗精神病治疗前后氨基酸及其衍生物生物胺的分析
Front Psychiatry. 2018 Apr 24;9:155. doi: 10.3389/fpsyt.2018.00155. eCollection 2018.
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The anxiolytic-like effect of 6-styryl-2-pyrone in mice involves GABAergic mechanism of action.6-苯乙烯基-2-吡喃酮在小鼠体内产生的抗焦虑样作用涉及 GABA 能作用机制。
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Ammonia-induced mitochondrial dysfunction and energy metabolism disturbances in isolated brain and liver mitochondria, and the effect of taurine administration: relevance to hepatic encephalopathy treatment.氨诱导的离体脑和肝线粒体功能障碍及能量代谢紊乱,以及牛磺酸给药的影响:与肝性脑病治疗的相关性
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Effect of taurine on chronic and acute liver injury: Focus on blood and brain ammonia.牛磺酸对急慢性肝损伤的影响:聚焦于血氨和脑氨。
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