Fertil Steril. 1983 May;39(5):647-55. doi: 10.1016/s0015-0282(16)47060-3.
The intra- and interwoman variation in nine physiologic or biochemical indices of the fertile period has been studied over 58 menstrual cycles from 13 experienced users of the symptothermal method of family planning by periodic abstinence. The time and duration of a possible fertile period have been determined by five methods (symptothermal, cervical mucus, basal body temperature plus calendar calculation, defined changes in the concentration of estrone-3-glucuronide and the ratio of estrone-3-glucuronide to pregnanediol-3 alpha-glucuronide as determined by immunochemical tests on daily samples of early morning urine). The values were compared with a period of probable fertility (day of urinary luteotropin [LH] peak -3 to day of LH peak +2). The duration of the possible fertile period by each method (mean +/- standard deviation) was 13.4 (2.9), 11.9 (2.9), 11.8 (3.3), 9.3 (2.2), and 10.9 (2.3) days, respectively, while the percentage of the probable fertile periods covered entirely by each approach was 98%, 91%, 90%, 83%, and 84%, respectively. The results warrant the initiation of clinical trials to ascertain the practical value of the individual or combined tests for family planning and the management of infertility.
通过定期禁欲，对13位采用症状体温法进行计划生育的经验丰富使用者的58个月经周期内，排卵期9项生理或生化指标的个体内及个体间差异进行了研究。通过5种方法（症状体温法、宫颈黏液法、基础体温加日历计算法、通过对晨尿每日样本进行免疫化学检测确定的雌酮-3-葡萄糖醛酸苷浓度的特定变化以及雌酮-3-葡萄糖醛酸苷与孕二醇-3α-葡萄糖醛酸苷的比率）确定了可能的排卵期时间和持续时间。将这些值与可能的生育期（尿促黄体生成素[LH]峰值前3天至LH峰值后2天）进行比较。每种方法确定的可能排卵期持续时间（平均值±标准差）分别为13.4（2.9）天、11.9（2.9）天、11.8（3.3）天、9.3（2.2）天和10.9（2.3）天，而每种方法完全覆盖可能生育期的百分比分别为98%、91%、90%、83%和84%。这些结果为开展临床试验以确定个体或联合检测在计划生育和不孕症管理中的实用价值提供了依据。
