Madsen H, Ditzel J
Am J Obstet Gynecol. 1982 Jun 15;143(4):421-4. doi: 10.1016/0002-9378(82)90084-9.
Parameters of red cell oxygen transport were studied in 23 nonsmoking, insulin-dependent diabetic women and 20 nonsmoking healthy women late during pregnancy. In the pregnant diabetic women, arterial oxygen saturation (SAT) and arterial oxygen tension were significantly decreased. SAT correlated inversely with hemoglobin Alc (Hb Alc) (diabetic women: r = -0.43, p less than 0.05; total material: r = 0.66, p less than 0.001). Red blood cell 2,3-diphosphoglycerate (2,3-DPG) was significantly increased in the pregnant diabetic women (p less than 0.01), but the 2,3-DPG-induced change in hemoglobin-oxygen affinity was impaired. P50 (oxygen affinity, i.e., Po2 at 50% oxygen saturation) at actual pH correlated inversely with Hb Alc of the diabetic women (r = -0.45, p less than 0.05). The suggestion is made that, in diabetic pregnancy, particularly in poorly regulated cases, fetal hypoxia may be an important factor of the increased risk of intrauterine fetal death.
对23名非吸烟的胰岛素依赖型糖尿病孕妇和20名非吸烟健康孕妇妊娠晚期的红细胞氧运输参数进行了研究。在妊娠糖尿病妇女中，动脉血氧饱和度（SAT）和动脉血氧分压显著降低。SAT与糖化血红蛋白（Hb Alc）呈负相关（糖尿病妇女：r = -0.43，p < 0.05；总体资料：r = 0.66，p < 0.001）。妊娠糖尿病妇女的红细胞2,3-二磷酸甘油酸（2,3-DPG）显著升高（p < 0.01），但2,3-DPG诱导的血红蛋白-氧亲和力变化受损。在实际pH值下的P50（氧亲和力，即血氧饱和度为50%时的氧分压）与糖尿病妇女的Hb Alc呈负相关（r = -0.45，p < 0.05）。有人提出，在糖尿病妊娠中，尤其是在控制不佳的情况下，胎儿缺氧可能是宫内胎儿死亡风险增加的一个重要因素。
