Dash B D, Patnaik B K
Gerontology. 1983;29(2):102-7. doi: 10.1159/000213100.
Mitochondrial respiration with succinate as substrate increased and the mitochondrial protein content declined in the brain of the ageing male garden lizard. The lactate/pyruvate ratio of both blood and brain did not show appreciable changes with advancing age. Cold-shock treatment induced a significant rise in the respiratory rate of brain mitochondria of young but not appreciably in that of middle-aged and old lizards. On the other hand both mitochondrial protein content and lactate/pyruvate ratio increased only in the brain of cold-shocked lizards of the old age-group. The lactate/pyruvate ratio in blood remained unaltered following cold-shock treatment of lizards of all three age-groups.
以琥珀酸为底物时，衰老雄性丽斑麻蜥大脑中的线粒体呼吸增加，而线粒体蛋白质含量下降。随着年龄增长，血液和大脑中的乳酸/丙酮酸比值均未出现明显变化。冷休克处理使幼年丽斑麻蜥大脑线粒体的呼吸速率显著升高，但中年和老年丽斑麻蜥的呼吸速率升高不明显。另一方面，只有老年组冷休克处理的丽斑麻蜥大脑中线粒体蛋白质含量和乳酸/丙酮酸比值增加。对所有三个年龄组的丽斑麻蜥进行冷休克处理后，血液中的乳酸/丙酮酸比值保持不变。
