Langhammer H R, Sondershaus S, Lauer O, Steuer G, Bauer R
Fortschr Med. 1983 Mar 17;101(10):429-34.
In a retrospective study of 728 patients with breast cancer up to 3 years after primary treatment skeletal scintigraphy yielded 15.8% (n = 115) bone metastases. By scintigraphic differentiation between a typical and an untypical pattern of bone metastasis a diagnostic accuracy of 99% was found. Depending on the local stage of tumor the rate of osseous metastases rises with increasing tumor size and with the extent of metastatic involvement of the lymph nodes. The frequency of bone metastasis proved to be also dependent on the histological type of tumor; it was highest in scirrhous carcinomas. By evaluating the scintigraphic behaviour of skeletal metastases under treatment in 122 patients we revealed an obvious decrease of metastatic deposits or complete normalization in 11.5% (n = 14), an unchanged finding in 32% (n = 39) and a progression of metastasis in 56.5% (n = 69). Therefore scintigraphic bone imaging in follow-up of breast cancer can be recommended for early detection of osseous metastases and for assessing the response of skeletal metastases to treatment.
在一项对728例乳腺癌患者进行的回顾性研究中，在初次治疗后长达3年的时间里，骨骼闪烁显像发现15.8%（n = 115）的患者出现骨转移。通过对典型和非典型骨转移模式进行闪烁显像鉴别，发现诊断准确率为99%。根据肿瘤的局部分期，骨转移率随肿瘤大小增加以及淋巴结转移受累范围的扩大而升高。骨转移的频率还被证明取决于肿瘤的组织学类型；在硬癌中最高。通过评估122例接受治疗的患者骨骼转移灶的闪烁显像表现，我们发现11.5%（n = 14）的患者转移灶明显减少或完全恢复正常，32%（n = 39）的患者表现无变化，56.5%（n = 69）的患者转移灶进展。因此，推荐在乳腺癌随访中进行骨骼闪烁显像，以早期发现骨转移并评估骨骼转移灶对治疗的反应。
