Sherlock S, Thomas H C
Hepatology. 1983 May-Jun;3(3):455-6. doi: 10.1002/hep.1840030327.
Assays for the detection of nucleic acid in serum are likely to be better systems for determining infectivity than indirect ones dependent on detection of virus-encoded proteins such as HBeAg. The hybridization assays are particularly useful in monitoring spontaneous or treatment-related conversion from the "replicative" to "nonreplicative" phase of HBV infection. The simplified technology described in the papers reported in this issue of Hepatology (9, 14) and their future adaptation to nonisotopic systems will rapidly bring these techniques into everyday clinical practice.
与依赖检测病毒编码蛋白（如HBeAg）的间接检测系统相比，血清中核酸检测方法可能是用于确定感染性的更好系统。杂交检测在监测HBV感染从“复制性”到“非复制性”阶段的自发或治疗相关转变方面特别有用。本期《肝病学》（第9篇、第14篇）报道的论文中描述的简化技术及其未来对非同位素系统的适应性将迅速把这些技术引入日常临床实践。
