登革病毒诱导的细胞毒性因子抑制小鼠对绵羊红细胞的免疫反应。
Dengue virus-induced cytotoxic factor suppresses immune response of mice to sheep erythrocytes.
作者信息
Chaturvedi U C, Shukla M I, Mathur K R, Mathur A
出版信息
Immunology. 1981 Jun;43(2):311-6.
Abstract
The present study was undertaken to investigate if the suppressed cell-mediated immune responses observed in dengue type 2 virus (DV)-infected mice could be due to the cytotoxic factor (CF) produced in the spleens of DV-infected mice. We have observed that CF given intravenously (i.v.) kills splenic cells and reduces the total cells in the spleen. Mice treated with CF have a significantly depressed immune response to sheep erythrocytes, viz. delayed-type-hypersensitivity as measured by footpad swelling reaction at 24 hr; Jerne's antibody plaque-forming cells in the spleen; and migration inhibition of spleen cells in presence of antigen. These findings are similar to those seen earlier in DV-infected mice.
摘要
本研究旨在调查在2型登革热病毒（DV）感染小鼠中观察到的细胞介导免疫反应受抑制是否可能归因于DV感染小鼠脾脏中产生的细胞毒性因子（CF）。我们观察到静脉内（i.v.）给予CF会杀死脾细胞并减少脾脏中的总细胞数。用CF处理的小鼠对绵羊红细胞的免疫反应明显受到抑制，即通过24小时足垫肿胀反应测量的迟发型超敏反应；脾脏中的耶尔恩抗体斑块形成细胞；以及在存在抗原时脾细胞的迁移抑制。这些发现与早期在DV感染小鼠中观察到的结果相似。
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