登革病毒诱导的抑制信号从巨噬细胞向淋巴细胞的传递是通过细胞接触实现的。
Transmission of dengue virus-induced suppressor signal from macrophage to lymphocyte occurs by cell contact.
作者信息
Shukla M I, Chaturvedi U C
出版信息
Br J Exp Pathol. 1983 Feb;64(1):87-92.
We have observed that live macrophages play an obligatory role in transmission of dengue type 2 virus (DV)-induced suppressor signal to a subpopulation of T lymphocytes. The present study was undertaken to resolve whether transmission of the suppressor signal is mediated by a soluble factor or by direct cell-to-cell contact. It was observed that the suppressor factor (SF) remains adsorbed on the surface of macrophages and can be retrieved from them completely by DV-stimulated spleen cells kept in contact with them. Suppression of DV-specific IgM plaque-forming cells (PFC) in spleen-cell cultures does not occur when SF-adsorbed macrophages are separated from them by cell-impermeable membranes. Culture fluid of SF-adsorbed macrophages have no suppressor activity. The suppression of PFC occurs only when SF-adsorbed macrophages remain in contact with DV-stimulated spleen-cell cultures. Thus transmission of suppressor signal from SF-adsorbed macrophages to lymphocytes occurs only by physical contact of the plasma membranes of the interacting cells.
我们已经观察到，活巨噬细胞在将登革2型病毒（DV）诱导的抑制信号传递给T淋巴细胞亚群的过程中发挥着不可或缺的作用。本研究旨在确定抑制信号的传递是由可溶性因子介导还是通过细胞间直接接触介导。结果发现，抑制因子（SF）仍吸附在巨噬细胞表面，并且可以被与它们接触的DV刺激的脾细胞从巨噬细胞表面完全回收。当用细胞不可渗透的膜将吸附有SF的巨噬细胞与脾细胞培养物分开时，脾细胞培养物中DV特异性IgM斑块形成细胞（PFC）的抑制作用不会发生。吸附有SF的巨噬细胞的培养液没有抑制活性。只有当吸附有SF的巨噬细胞与DV刺激的脾细胞培养物保持接触时，PFC的抑制作用才会发生。因此，抑制信号从吸附有SF的巨噬细胞向淋巴细胞的传递仅通过相互作用细胞的质膜的物理接触发生。
Zotero 插件